In the paper, Sulniute et al. show that plasminogen is transported to the wound by inflammatory cells early during the healing process, where it potentiates inflammation and how lack of plasminogen leads to extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation.
Sulniute R, Shen Y, Guo YZ, Fallah M, Ahlskog N, Ny L, Rakhimova O, Broden J, Boija H, Moghaddam A, Li J, Wilczynska M, Ny T.Thromb Haemost. 2016 May 2;115(5):1001-9. doi: 10.1160/TH15-08-0653. Epub 2016 Jan 21.